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Nitrous oxide was tested for carcinogencity by inhalation in mice and rats. In one limited study in mice in which exposure started in utero, no treatment related neoplasm was observed [ref14]. No carcinogenic effect was seen in rats exposed chronically to a low dose of nitrous oxide alone or in combination with halothane [ref16]. C.

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The US Pharmacopeial Convention (USP) is a scientific nonprofit organization that sets standards for the identity, strength, quality, and purity of medicines, food ingredients, and dietary supplements manufactured, distributed and consumed worldwide. USP's drug standards are enforceable in the United States by the Food and Drug Administration.

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Cosmetics are different from drugs, which are defined as "articles intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease" and "articles (other than food) intended to affect the structure or any function of the body of man or other animals." This difference is important when it comes to federal oversight of

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